Abstract
Radix Angelica Sinensis, the dried root of Angelica sinensis (Danggui), is a herb used in Chinese medicine to enrich blood, promote blood circulation and modulate the immune system. It is also used to treat chronic constipation of the elderly and debilitated as well as menstrual disorders. Research has demonstrated that Danggui and its active ingredients, as anti-arthrosclerotic, anti-hypertensive, antioxidant anti-inflammatory agents which would limit platelet aggregation, are effective in reducing the size of cerebral infarction and improving neurological deficit scores.
Highlights
Danggui, the dried root of Angelica Sinensis (Radix Angelica Sinensis), is a commonly used Chinese medicinal herb to enrich blood, promote blood circulation and treat blood deficiency pattern and menstrual disorders such as dysmenorrhea and irregular menstrual cycle [1]
Under electromicroscopy the morphology of endothelial cell was damaged which was reversed by Danggui (20 mg/ml) and its component of sodium ferulate (0.3 mg/ml). These results indicate that both Danggui and sodium ferulate have anti-atherogenic effects [24]
Ferulic acid exerts anti-inflammatory action by reducing the generation of 4-hydroxy-2-nonenal (4-HNE), 8-hydroxy-2’-deoxyguanosine (8-OHdG) and apoptosis in the reperfusion period after cerebral ischemia, providing neuroprotection [32]. This neuro-protection by ferulic acid is thought to occur via enhancing gamma-aminobutyric acid type B1 (GABAB1) receptor expression to against p38 mitogen activated protein kinase (MAPK)-mediated Nitric oxide (NO)-induced apoptosis [34]
Summary
The dried root of Angelica Sinensis (Radix Angelica Sinensis), is a commonly used Chinese medicinal herb to enrich blood, promote blood circulation and treat blood deficiency pattern and menstrual disorders such as dysmenorrhea and irregular menstrual cycle [1]. Ferulic acid (eg 80 and 100 mg/kg, i.v.) reduces the size of cerebral infarction and neurological deficit scores and inhibits ICAM-1 and NF-B expression in transient MCAo rats [33]. Ferulic acid (eg 100 mg/kg, i.v.) exerts anti-inflammatory action by reducing the generation of 4-hydroxy-2-nonenal (4-HNE), 8-hydroxy-2’-deoxyguanosine (8-OHdG) and apoptosis in the reperfusion period after cerebral ischemia, providing neuroprotection [32] This neuro-protection by ferulic acid is thought to occur via enhancing gamma-aminobutyric acid type B1 (GABAB1) receptor expression to against p38 mitogen activated protein kinase (MAPK)-mediated NO-induced apoptosis [34]. Danggui reduced the size of cerebral infarction, neurological deficit scores and increased blood flow and SOD activity in the MCAo rat model [44]. Danggui reduces the size of cerebral infraction and improves neurological deficit scores
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