Pharmacological effects of Oleum Cinnamomi and water extract of Cortex Cinnamomi in rats with yang-deficiency cold syndrome and the mathematical analysis

Abstract

To compare the effects of Oleum Cinnamomi and water extract of Cortex Cinnamomi in rats with yang-deficiency cold syndrome based on mathematical analysis. A total of 48 male Sprague-Dawley rats were randomly divided into 4 groups (normal, model, Oleum Cinnamomi and water extract of Cortex Cinnamomi). Yang-deficiency cold syndrome was induced by hydrocortisone sodium succinate. Oleum Cinnamomi and water extract of Cortex Cinnamomi were given by gastrogavage daily for one week to respective groups. Material metabolism indexes such as glucose (GLU), uric acid (UA), total cholesterol (TC), triacylylyceral (TAG), total protein (TP) and albumin (ALB); energy metabolism indexes such as lactic acid (LAC), lactate dehydrogenase (LDH), succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase); endocrine system indexes such as corticosteroid (CS), triiodothyronine (T3), tetraiodothyronine (T4), thyroid stimulating hormone (TSH), estradiol (E(2)), vitamin C (VC) and 17-hydroxycorticosteriod (17-OHCS); and immune system indexes such as immunoglobulin M (IgM), immunoglobulin G (IgG), complement 3 (C3) and complement 4 (C4) were measured. And then the data were analyzed by mathematical analysis method. Oleum Cinnamomi and water extract of Cortex Cinnamomi had similar influence on some indexes of material metabolism, energy metabolism and endocrine and immune systems in rats with yang-deficiency cold syndrome. Positive effects were showed in GLU, TC, TAG, TP, ALB, IgM, E(2), CS, VC and 17-OHCS. Water extract of Cortex Cinnamomi had no significant effects on TSH, LAC and SDH, but Oleum Cinnamomi had, while water extract of Cortex Cinnamomi had significant effects on ATPase, LDH and IgG. There is a complex relationship between Oleum Cinnamomi and water extract of Cortex Cinnamomi in their effects on rats with yang-deficiency cold syndrome. They have similar property, however, disparities exist between them to some extent. The exact mechanism needs further research.