Abstract
Objective: a comparative analysis of the pharmacological effects of proserin during a drug test with low-frequency direct muscle stimulation by the method of stimulated impedance myography while controlling the effect of thimectomy.Materials and methods. Patients suffered myasthenia gravis, which had thymoma, were investigated before and after thymectomy by means stimulative impedance myography method. Neostigmine test and low frequency 1.0 Hz direct needle muscle stimulation during 3 minutes were used. Amplitude of direct and transsynaptical evoked contractive reactions were measured in parallel researches.Results. Results of researches of control group showed normal amplitude dispersion; meanwhile patients after neostigmine injection had right-side asymmetric dispersion and intermittent contractility. The amplitude transsynaptical contraction before thymectomy rose up on 14.0 %, meanwhile after operation – 29.0 %.Conclusion. Probably neostigmine fell down threshold level of motor nerve terminals and made proposal to their excitationи by big impulses surrounded muscle fibers and impulses of stimulator.
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