Abstract
Ovulation constitutes the central event in ovarian physiology, and ovulatory disfunction is a relevant cause of female infertility. Non-steroidal anti-inflammatory drugs (NSAIDs), widely used due to their analgesic and anti-inflammatory properties, consistently inhibit ovulation in all mammalian species investigated so far, likely due to the inhibition of cyclooxygenase that is the rate limiting enzyme in prostaglandin (PG) synthesis.Short -term administration of low-dose (aspirin, mefenamic acid buprofen & meloxicam) to female mice at proestrous cause a highly significant decrease in the ovulatory rate as compared to controls .Greater effect were produced by meloxicam.
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