Pharmacological effect on pyeloureteric dynamics with a clinical perspective: a review of the literature

Abstract

We searched to review experimental and clinical trials concerning the capabilities of impacting on the ureteric and pelvic activity by means of pharmacological stimulation. Ureteropyeloscopy may cause high renal pelvic pressure. The normal pressure is in the range of 5-15 mmHg whereas pressure of 410 mmHg has been measured during endoscopy. The threshold pressure for intrarenal reflux is about 35 mmHg. Studies in animals have revealed that high renal pelvic pressures may cause permanent damage to the renal parenchyma. Furthermore, it has been demonstrated that elevated pressures may entail an increased risk of several complications related to endourological procedures including bleeding, perforation and infection. In other words, means by which intrarenal pressure could be lowered during endourological procedures might be beneficial with respect to clinical outcomes. In vitro experiments support the existence of different receptors in the ureter and renal pelvis. The ureteric and pelvic responses to the corresponding neurotransmitters have been determined. It seems that alpha-adrenergic and cholinergic agents are stimulating whereas beta-adrenergic agents inhibit ureteric activity. The effect may depend on the mode of administration. Drugs exerting advantageous effects in the pyeloureter may cause undesirable systemic side effects when administered intravenously. In animal studies, renal pelvic pressure can be significantly lowered by topical administration of beta-adrenergic agonists without systemic side effects. In vivo human studies are necessary to clarify the exact dose-response relationship and the degree of urothelial absorption of a drug before clinical use may be adopted.