Abstract
Introduction: The leading role of pathogenic microorganisms in the pathogenesis of periodontitis is beyond doubt. However, the use of antibiotics for periodontitis is associated with a number of problems. Indolicidins have a unique anti-microbial effect. The relevance of the search for new drugs for the treatment of acute periodontitis based on the natural indolicidin peptide becomes obvious.
 Materials and methods: The investigation was performed on 320 Wistar male rats, using synthetic analogues of natural indolicidin: No. 7 and No. 8, which were administered intraperitoneally at a dose of 500 µg/kg in a volume of 0.2 ml once a day for 7 days. Periodontitis was simulated in animals according to the method proposed by Volozhin A.I. and Vinogradova S.I.
 Results and discussion: The correcting effect of indolicidin analogues on the periodontitis course, was manifested by a decrease in edema and in the relative area of cell infiltrates, a significant increase in the relative area of normal tissue, and a correction of the periodontal composition. The use of indolicidin analogues led to an increase in the functional activity of neutrophils and macrophages, acute phase proteins concentration, a correction of pro-oxidantantioxidant balance and production of vasoactive substances. The effect of indolicidin analogues was higher than that of lincomycin. The greater effectiveness of peptide No.8 compared to that of No.7 was established.
 Conclusion: The investigation opens up the prospects of the synthesis of new antimicrobial drugs on the basis of the synthetic analogues of indolicidin.
Highlights
The leading role of pathogenic microorganisms in the pathogenesis of periodontitis is beyond doubt
The results suggest that indolicidins No.7 and No.8 have a corrective effect on the development of acute periodontitis, which is manifested by a decrease in the swelling, a reduction of the relative area of cellular infiltrates and a significant increase in the relative area of normal tissue
The investigation revealed that the administration of synthetic analogues of indolicidin No.7 and No.8 is an effective method of pharmacological correction of periodontitis (Fig. 1)
Summary
The leading role of pathogenic microorganisms in the pathogenesis of periodontitis is beyond doubt. The relevance of the search for new drugs for the treatment of acute periodontitis based on the natural indolicidin peptide becomes obvious. Periodontitis was simulated in animals according to the method proposed by Volozhin A.I. and Vinogradova S.I. Results and discussion: The correcting effect of indolicidin analogues on the periodontitis course, was manifested by a decrease in edema and in the relative area of cell infiltrates, a significant increase in the relative area of normal tissue, and a correction of the periodontal composition. Its prevalence among the adult working-age population reaches 75% (Tsepov et al 2014) In this case, periodontitis leads to the loss of a large number of intact teeth, as well as the emergence of foci of chronic infection due to the formation of gingival and periodontal pockets, which contributes to the formation of somatic pathology.
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