Abstract
1. 1. Uterine motility was studied in vitro in the myometrial tissue obtained from pregnant and non-pregnant mares. 2. 2. The spontaneous contractions of the preparations were not modified by tetrodotoxin, by anticholinergics, antiadrenergics, histamine H1 and H2 blockers, antiserotoninergic and opioid antagonists; but disappeared in Ca 2+ and Na + free medium. 3. 3. β 2-adrenergic stimulants like salbutamol and hexoprenaline and the calcium channel blockers nifedipine and verapamil were effective inhibitors of the amplitude of phasic contractions (ID 50s for salbutamol and nifedipine were 7.7 nM and 14.6 nM, respectively in oestrus preparations). 4. 4. The above data indicated that the mare myometrium contractility in vitro is very sensitive to the action of β 2 mimetic compounds and calcium antagonists; nifedipine, in particular, seems to be a very promising alternative to β 2 stimulants in the tocolytic therapy.
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