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Abstract
1. 1. The effects of adenosine 5′-triphosphate (ATP), 2-methyl-thio-ATP and adenosine on rabbit aorta were examined in isolated preparations precontracted by noradrenaline, both in vessels where the endothelium was present and mechanically removed. 2. 2. In the presence of endothelium, ATP (30 μM-3 mM) induced a relaxation that was reduced by removal of the endothelium. 3. 3. The maximum endothelium-dependent relaxation of ATP was twice the maximum endothelial activity of the potent agonist at P 2y-purinoceptors, 2-methyl-thio-ATP. 4. 4. Adenosine which acts on P 1 purinoceptors, induced a relaxant effect at 1 mM concentration, both in the vessels with and without endothelium. 5. 5. It is concluded that relaxation by ATP is induced both via the endothelial P 2y-purinoceptor and via a “nucleotide” receptor that is located on endothelium and on smooth muscle of rabbit aorta.
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