Abstract
Allergic rhinitis (AR) is considered a major nasal condition impacting a large number of people around the world, and it is now becoming a global health problem. Because the underlying mechanisms of AR are complex, the development of single-drug treatment might not be enough to treat a wide spectrum of the disease. Although the standard guidelines classify and provide suitable diagnosis and treatment, the vast majority of people with AR are still without any means of controlling it. Moreover, the benefits of AR drugs are sometimes accompanied by undesirable side effects. Thus, it is becoming a significant challenge to find effective therapies with limited undesirable side effects for a majority of patients suffering from uncontrolled AR. Aller-7/NR-A2, a polyherbal formulation, has revealed promising results in patients by reducing nasal symptoms and eosinophil counts without serious adverse effects. Interestingly, three out of seven of the herbals in the Aller-7/NR-A2 formulation are also found in an Ayurvedic polyherbal formulation known as “Triphala,” which is a potential candidate for the treatment of AR. However, there are no current studies that have examined the effects of Triphala on the disease. This review aims to describe the complexity of AR pathophysiology, currently available treatments, and the effects of Triphala on AR in order to help develop it as a promising alternative treatment in the future.
Highlights
Allergic rhinitis (AR), commonly known as hay fever, is not considered a serious condition or one with the potential for mortality, it might become a clinical burden if it were to become uncontrollable in a majority of patients
The results strongly suggest the benefits of using T. chebula Retz. extract for treating AR because the shifting of immunity from T helper 2 (Th2) to Th1 is used to define a successful response following treatment with allergen-specific immunotherapy (AIT) (Lam et al, 2020), and alteration of Th2 cytokines by reducing the Th2 response may offer a kind of protective effect in treating allergic diseases (Bosnjak et al, 2011)
Experimental data from previous in vitro and in vivo studies of Triphala or individual plants in this remedy have demonstrated potential natural compounds that may be the main acting molecules able to promote the attenuation of AR symptoms
Summary
Allergic rhinitis (AR), commonly known as hay fever, is not considered a serious condition or one with the potential for mortality, it might become a clinical burden if it were to become uncontrollable in a majority of patients. Epidemiological studies have revealed that patients with AR have a high probability of subsequently developing asthma, and a large proportion of asthmatic patients have AR as a concomitant condition (Simons, 1999; Thomas, 2006; Vujnovic and Domuz, 2018). Prolonged AR symptoms, nasal congestion, can lead to the development of obstructive sleep apnea (Young et al, 1997). To achieve final outcomes, it is often suggested to patients that they use long-term multiple therapies, which sometimes come with problems of compliance, leading to failures in treatment (Small et al, 2018). Combinations of two drugs in one device, such as antihistamine/steroid or anticholinergic/steroid, are becoming
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