Abstract
BackgroundThe present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects. Therefore, new effective agents are the most wanted. The present study investigates the anti-nociceptive, anti-inflammatory and antipyretic activities of crude methanol extract of Hypericum oblongifolium.MethodsIn vivo acetic acid induced writhing and hot plate tests were used for antinociceptive effects at 100, 200 and 300 mg/kg i.p. The anti-inflammatory and antipyretic potential of methanol extract were tested in carrageenan induced paw edema in mice and yeast induced hyperthermia respectively.ResultsThe extract doses of 100, 200 and 300 mg/kg i.p. revealed significant inhibitory effect (P < 0.001) in acetic acid induced writhing test. Pretreatment of extract at doses of 100, 200 and 300 mg/kg i.p. produced significant anti-inflammatory effect (P < 0.001) in the carrageenan induced paw edema. The methanol extract also showed significant antipyretic effect in yeast induced hyperthermia in mice during various assessment times.ConclusionsThe methanol extract of H. oblongifolium showed significant anti-nociceptive, anti-inflammatory and antipyretic effects in various animal models and thus validates the traditional uses of the plant in said conditions.
Highlights
The present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects
Significant increase (P < 0.001) in the latency time was noticed with the standard opioid analgesic (Tramadol) after 30, 60 and 90 min
Anti-inflammatory activity As shown in Fig. 3, significant protection (P < 0.001) from carrageenan induced inflammation was exhibited by Hypericum oblongifolium methanol extract (HOME) at doses of 100, 200 and 300 as compared to saline treated group
Summary
The present therapeutic agents for the treatment of pain, inflammation and pyrexia are not very effective and accompanied by various side effects. Allopathic medicine uses drug treatments to decrease the inflammation and pyrexia as well as reduce the pain by blocking various inflammatory mediators especially the prostaglandins, leukotrienes, cytokines and histamine. These medications often cause side effects such as stomach bleeding, bone demineralisation, kidney damage and nutritional deficiencies [1, 2]. Dyes, pigments, timbers, gums and resins have been isolated from its different members [7] This genus is widely studied for anti-depressant, anti-microbial, antioxidant, antiviral, anxiolytic, anticancer, anti-inflammatory and anti-ulcerogenic activities. Several species of this genus especially Hypericum perforatum [8], Hypericum caprifoliatum [9, 10], Hypericum polyanthemum [11, 12], and Hypericum grandifolium [13, 14] were extensively studied for their utility in different diseases like depression, seasonal effective disorder, HIV and hepatitis-C infection, obsessive compulsive disorder, as well as other
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
