Abstract
Contraction parameters of phrenic nerve hemidiaphragm preparations from the athymic mutant mouse ( nu nu ) were not significantly different from controls. The sensitivity of these preparations to neuromuscular blocking drugs was increased whereas their sensitivity to physostigmine was reduced. Biochemical estimates revealed greater cholinesterase activity in muscle from mutant animals, and that the activity increased with age. The significance of these observations in relation to thymic secretions is briefly discussed and it is concluded that further study on preparations from this animal will help to establish the role of the thymus in normal neuromuscular function.
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