Pharmacological and Toxicological evaluation of selenium in combination with thiamine in chemically induced hepatocarcinogenesis

Abstract

Hepatocellular carcinoma (HCC) is currently holding the second rank as a fatal cancer globally. Our hypothesis projects the combined effect of selenium (3mg/kg) and thiamine in combination as an effective treatment for DENA induced carcinogenesis in Wistar rats with an intra-peritoneal single dose of 200mg/kg body weight. Data obtained proved to show a remarkable alteration in body weight and liver profile of DENA exposed rats which were restored by administration of selenium and thiamine combination; our histological reports also revealed reparative changes in the trabaculie mesh work of hepatic cells at higher doses than the normal dietary requirement. Outcomes of the protocol showed remarkable fruitful results for the justification of combined selenium and thiamine as anticancer therapy.