Pharmacological and Behavioral Comparative Study of Allium Cepa Linn. Bulb and Coffee with Bhavana Treatment in Rats

Abstract

Objective: To evaluate and compare the effects of Allium cepa Linn. bulb and coffee with Bhavana treatment on the central nervous system of the rats. Materials and methods: Female Wistar Albino rats weighing 300-350 gm were used to study the effect of Allium cepa Linn. juice and coffee with bhavana treatment on anxiety, pain, muscle co-ordination and learning and memory. The following methods were used elevated plus maze model of anxiety, hot plate analgesiometer method for evaluating analgesic activity, Rotarod test for evaluating effect on muscle coordination while learning and memory was evaluated by using Morris water maze test. Results: Combination of coffee and Allium cepa Linn. juice by Bhavana treatment showed an increase in the reaction time on the hot-plate method on repeated administration and was found to be a similar to the positive control. It also showed a variable and marginal effect on learning and memory of the rats. Conclusion: Comparative analysis showed a significant difference between the activities of Linn. juice and coffee individually and its combination by Bhavana treatment