Abstract
Soursop (Annona muricata Lin.) is a plant belonging to the Annonaceae family that has been widely used globally as a traditional medicine for many diseases. In this review, we discuss the traditional use, chemical content, and pharmacological activities of A.muricata. From 49 research articles that were obtained from 1981 to 2021, A.muricata’s activities were shown to include anticancer (25%), antiulcer (17%), antidiabetic (14%), antiprotozoal (10%), antidiarrhea (8%), antibacterial (8%), antiviral (8%), antihypertensive (6%), and wound healing (4%). Several biological activities and the general mechanisms underlying the effects of A.muricata have been tested both in vitro and in vivo. A.muricata contains chemicals such as acetogenins (annomuricins and annonacin), alkaloids (coreximine and reticuline), flavonoids (quercetin), and vitamins, which are predicted to be responsible for the biological activity of A. muricata.
Highlights
The use of natural ingredients as treatments for various diseases is increasing
We provide an overview of the botanical description, traditional uses, compounds, and pharmacological activities of A. muricata
We summarized the existing literature relevant to A. muricata, its compound contents, pharmacological activities, and the mechanisms of its pharmacological activity published during the period of 1981–2021
Summary
The use of natural ingredients as treatments for various diseases is increasing. Plants are a source of natural ingredients that are widely used as medicines. Their contents, and the pharmacological activities of their constituents have been conducted. A. muricata L. contains various compounds with pharmacological activity. This plant is widely grown in tropical and subtropical areas, such as Southeast Asia, South America, and the rainforests of Africa. The plant produces edible fruit all year round and is widely used as a traditional medicine for skin disease, respiratory disease, fever, bacterial infections, diabetes, hypertension, and cancer [1,2]. We provide an overview of the botanical description, traditional uses, compounds, and pharmacological activities of A. muricata. We summarized the existing literature relevant to A. muricata, its compound contents, pharmacological activities, and the mechanisms of its pharmacological activity published during the period of 1981–2021
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