Abstract
Intraperitoneal administration of the ethanol extract of Grewia bicolor root (300 mg kg ) to rats in early pregnancy ( +1 – 4 days) did not affect the number of conception sites, but significantly increased resorption. In late pregnancy (+19–20 days), the extract (300 mg kg ) did not affect duration of the gestation period; however, 400 mg kg was lethal to all mother rats. The active compound, apparently a peptide, exerted a serotonin-like effect on rat uterus, rat fundus and rabbit jejunum. All these effects were abolished by methysergide. A transient serotonin-like rise in cat blood pressure was produced by the active fraction and this effect was also blocked by cyproheptadine.
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