Abstract
Introduction. Propolis is one of the products made by bees and its chemical composition depends on the region, available plant species and climatic conditions. Among the 13 types of propolis produced in Brazil, green, red and brown are the main ones. Objective. To present the pharmacological properties of Brazilian green propolis observed through experiments involving animals and humans. Methodology. Careful research of articles published from 2017 to 2022 was conducted at Pub-Med, Science direct, Embase and Scielo, focusing on the pharmacological effects of Brazilian green propolis or its constituents observed in clinical trials. Results and discussion. Published results suggest that short- or long-term administration of propolis does not cause toxic effects. Pharmacokinetic studies show that terpenes, such as artepillin C and drupanin, are the main active constituents. Conclusion. For decades the Brazilian green propolis pe used in the treatment and prevention of diseases. However more specific studies are suggested to clarify the pharmacokinetics of green propolis, to establish safe and more effective doses.
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