Abstract
It is well known that nicotine and l,l-dimethyl-4-phenylpiperazinium (DMPP) have biphasic chronotropic responses both by stimulating the intracardiac parasympathetic ganglia and by liberating catecholamines locally (1-4). In 1967, Nadeau and James reported effects of nicotine on heart rate using a direct perfusion technique of the SA node in dogs (5). They showed that the negative chronotropic response to nicotine was abolished by treatment with atropine and that of the positive by either propranolol or hexamethonium. Furthermore, Bhagat et al. reported that nicotine-induced acceleration of sinus rate was inhibited by hexamethonium but the DMPP-induced one was not suppressed by hexamethonium in isolated guineapig atria (6).
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