Abstract
Pharmacokinetic of clavulanic acid (C.A.) was studied in newborns and children in combination with amoxicillin (Augmentin) or Ticarcillin (Timentin). Augmentin was administered by 30 mn IV. infusions:100 mg amox/10 mg CA/kg/day before 3 months, 100-200 mg amox./10-20mg CA/kg/day after 3 months (4 infusions in children, 2 infusions in newborn period). Timentin was given identically : 250 mg TIC/10 mg CA/kg/day before 3 months, 300 mg TIC/20 mg CA/kg/day after 3 months. 8 newborns and 6 children were treated by Augmentin, 3 newborns and 10 children by Timentin. Serum levels were determined by microbiological method. Results are in the table I:These results suggest the usefulness of 4 infusions/day, to maintain inhibitor serum level of C.A. active against beta-lactamases.
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