Pharmacokinetics study of sweet corn cob polysaccharide nano emulsion microcapsules

Abstract

Fluorescein isothiocyanate (FITC) was used for the fluorescent labeling of sweet corn cob polysaccharide (SCP), followed by identification using fluorescence spectroscopy, UV–Visible spectroscopy, infrared spectroscopy, and NMR analysis. The results confirmed the successful attachment of FITC to SCP with a substitution degree of 1.28%. This established fluorescent sweet corn cob polysaccharide (FSCP) was then subjected to an in vivo quantitative analysis, in which mice were administered with FSCP, fluorescent sweet corn cob polysaccharide nanoemulsion (FSCP-NE), and fluorescent sweet corn cob polysaccharide nano emulsion microcapsule (FSCP-NE-ME) via gavage followed by investigating the in vivo plasma pharmacokinetics and tissue distribution. The results revealed that FSCP-NE could improve the utilization efficiency of SCP, and the FSCP-NE microcapsules exhibited good controlled-release performance, which significantly improved the utilization efficiency of SCP. The absorption and metabolism of SCP in vivo were explored next, which provided the reference for future research and development on SCP for application in the fields of nutraceuticals and pharmaceuticals.