Abstract
The study aimed toevaluate and compare the routes and rates ofthe depletion ofthe antiparasitic praziquantel (PZQ), aderivative ofpyrazinoisoquinoline, following its oral administration ingrass carp (Ctenopharyngodon idella). Wefocused onthe depletion ofPZQ and its major metabolites - cis-hydroxy praziquantel (CPZQ) and trans-hydroxy praziquantel (TPZQ), inwater, the plasma, hepatopancreas, kidney, muscle, and skin, following asingle oral administration ofPZQ inaconcentration of50mg/kg. Fish were sampled before the drug administration and then eight times inthe course ofthe 30-day-long experiment. Our results indicate the rapid absorption and elimination ofPZQ and its metabolites inall the analysed matrices. The most PZQ-burdened tissue was the hepatopancreas, the gill and the skin. Inall the samples, the concentration ofthe drug and its metabolites consistently declined over time. The residue ofthe parent compound was detected for the longest time inall thetissues. During the study, asignificant (P<0.01) correlation was found within the concentration ofPZQ, CPZQ, and TPZQ inthe water and all the biological matrices. Itwas also found that the PZQ residue was not detected below the maximum residue levels (i.e., 20μg/kg) until 16 days after exposure inthe muscle and skin.
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