Abstract
The introduction of CAPD has renewed interest in peritoneal dialysis as a method for treating end-stage renal disease. The most frequent complication, peritonitis, is also the most frequent cause of failure of the technique. Peritonitis occurring during CAPD is clinically different from that following a surgical insult. Patients undergoing CAPD usually suffer some external contamination leading to infection. Dialysis therapy is used for treatment of infection. Effective antibiotic therapy must not only provide adequate serum and tissue levels, but must also be able to eradicate organisms that may persist in stagnant residual pools of dialysate within the peritoneal cavity. Thus, it would seem reasonable to attempt to obtain both adequate serum levels and dialysate concentrations.
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