Pharmacokinetics of transdermal flunixin in sows.

Abstract

The objective of this study was to describe the pharmacokinetics (PK) of flunixin in 12 nonlactating sows following transdermal (TD) flunixin (3.33mg/kg) and intravenous (IV; 2.20mg/kg) flunixin meglumine (FM) administration using a crossover design with a 10-day washout period. Blood samples were collected postadministration from sows receiving IV FM (3, 6, 10, 20, 40min and 1, 3, 6, 12, 16, 24, 36, and 48hr) and from sows receiving TD flunixin (10, 20, 40min and 1, 2, 3, 4, 6, 8, 12, 16, 24, 36, 48, 60, and 72hr). Liquid chromatography and mass spectrometry were used to determine plasma flunixin concentrations, and noncompartmental methods were used for PK analysis. The geometric mean±SD area under the plasma concentration-time curve (AUC) following IV injection was 26,820.59±9,033.88 and 511.83±213.98hrng/ml for TD route. Mean initial plasma concentration (C0 ) was 26,279.70±3,610.00ng/ml, and peak concentration (Cmax ) was 14.61±7.85ng/ml for IV and TD administration, respectively. The percent mean bioavailability of TD flunixin was 1.55±1.00. Our results demonstrate that topical administration is not an efficient route for delivering flunixin in mature sows.