Abstract
Tilmicosin was administered to goats intravenously and subcutaneously to determine its concentration in blood and milk and its kinetic behaviour. After a slow intravenous injection, the serum concentration-time curve indicated a two compartment open model with a mean (SEM) elimination half-life (t1i2p) of 4·36 (0·04) hours. After a subcutaneous injection the drug was eliminated more slowly from serum and milk, with t1/20s of 29·3 and 41·4 hours, respectively. The apparent volume of distribution of tilmicosin was more than 1 litre kg −1. The peak serum tilmicosin concentration was 1·56 pg ml −1 6·39 hours after a subcutaneous injection of 10 mg kg −1. Tilmicosin was extensively secreted into milk, reaching a maximum concentration of 11·6 lug ml −1 and having a large AUC milk/AUC serum ratio of approximately 12:1. Tilmicosin was detectable in milk for 11 days after a single subcutaneous dose.
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