Pharmacokinetics of three formulations of vitacoxib in horses.

Abstract

The pharmacokinetic properties of three formulations of vitacoxib were investigated in horses. To describe plasma concentrations and characterize the pharmacokinetics, 6 healthy adult Chinese Mongolian horses were administered a single dose of 0.1mg/kg bodyweight intravenous (i.v.), oral paste, or oral tablet vitacoxib in a 3-way, randomized, parallel design. Blood samples were collected prior to and at various times up to 72hr postadministration. Plasma vitacoxib concentrations were quantified using UPLC-MS/MS, and pharmacokinetic parameters were calculated using noncompartmental analysis. No complications resulting from the vitacoxib administration were noted on subsequent administrations, and all procedures were tolerated well by the horses throughout the study. The elimination half-life (T1/2λz ) was 4.24±1.98hr (i.v.), 8.77±0.91hr (oral paste), and 8.12±4.24hr (oral tablet), respectively. Maximum plasma concentration (Cmax ) was 28.61±9.29ng/ml (oral paste) and 19.64±9.26ng/ml (oral tablet), respectively. Area under the concentration-versus-time curve (AUClast ) was 336±229nghr/ml (i.v.), 221±94nghr/ml (oral paste), and 203±139nghr/ml, respectively. The results showed statistically significant differences between the 2 oral vitacoxib groups in Tmax value. T1/2λz (hr), AUClast (nghr/ml), and MRT (hr) were significantly different between i.v. and oral groups. The longer half-life observed following oral administration was consistent with the flip-flop phenomenon.