Abstract
Over a 1 yr period, 15 ingestions of thyroxine in children under 5 yrs of age were evaluated. All patients had initial serum T4 levels determined within 7 hrs of ingestion. Multiple T3 and T4 serum levels were determined in 7 patients. Peak T4 levels ranged from 16-118 mog/dl with 3 patients >75 mog/dl. The estimated peak T4 level occurred <12 hrs in 71% of the patients; the estimated peak T3 level occurred >20 hrs in 71% of the patients. In 5 patients who received no specific treatment, the mean serum T4 t1/2 was 2.84 da (range 1.7-4.54 da) and the mean serum T3 t1/2 was 5.1 da (range 1.9-12.3 da). Specific therapy to inhibit conversion of T4 to T3 was given in 2 patients during which serum t1/2 were: We conclude that in acute pediatrio overdose of thyroxine: (1) peak T4 levels occur earlier than peak T3 levels, (2) in untreated patients the t1/2 of T4 is shorter than T3, and (3) shortly after administration, PTU and iopanoic acid can prolong T4 t1/2 and shorten T3 t1/2.
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