Abstract
The disposition of phosphonomycin following intravenous administration is adequately described by a two-compartment open model. Pharmacokinetic parameters derived from serum concentration data correctly predict the urinary excretion profile for the same individual. Lack of self-consistency between serum and urine profiles at any time is in every case accompanied by apparent deviations in renal clearance rate. The adequacy of the model is further illustrated by the good agreement between serum and urinary excretion profiles predicted with pharmacokinetic parameters derived for individual subjects and those actually observed on repeated administration to the same subjects.
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