Abstract
The disposition kinetics of norfloxacin, after intravenous, intramuscular and subcutaneous administration was determined in rabbits at a single dose of 10mg/kg. Six New Zealand white rabbits of both sexes were treated with aqueous solution of norfloxacin (2%). A cross-over design was used in three phases (2×2×2), with two washout periods of 15days. Plasma samples were collected up to 72hr after treatment, snap-frozen at -45°C and analysed for norfloxacin concentrations using high-performance liquid chromatography. The terminal half-life for i.v., i.m. and s.c. routes was 3.18, 4.90 and 4.16hr, respectively. Clearance value after i.v. dosing was 0.80L/h·kg. After i.m. administration, the absolute bioavailability was (mean±SD) 108.25±12.98% and the Cmax was 3.68mg/L. After s.c. administration, the absolute bioavailability was (mean±SD) 84.08±10.36% and the Cmax was 4.28mg/L. As general adverse reactions were not observed in any rabbit and favourable pharmacokinetics were found, norfloxacin at 10mg/kg after i.m. and s.c. dose could be effective in rabbits against micro-organisms with MIC ≤0.14 or 0.11μg/mL, respectively.
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