Abstract
Objective:We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs.Materials and Methods:The dogs were administered IV AA at two doses of 1.5 and 3 gm/kg for 4 h, and the AA concentration in plasma and urine pH was measured before and after administration.Results:The plasma concentrations of AA in both groups peaked 3 h after administration. Among the two groups, the urine pH was not significantly different (p = 0.1299–0.7944). High-dose IV AA did not induce serious adverse events in dogs.Conclusion:The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs.
Highlights
Ascorbic acid (AA) is used at a high dose to selectively kill cancer cells when the plasma concentration exceeds 0.3–20 mM [1,2,3]
We performed a randomized two-way crossover study to evaluate the pharmacokinetic profiles of two high-dose ascorbic acid (AA) after IV infusion in healthy beagle dogs
The results of this study suggest that the high dose of AA which reaches the therapeutic dose for cancer and supports the safety of high-dose IV AA in dogs
Summary
Ascorbic acid (AA) is used at a high dose to selectively kill cancer cells when the plasma concentration exceeds 0.3–20 mM [1,2,3]. High doses of IV AA increase plasma and tumor AA concentrations, which are maintained for three times longer than that in plasma. Increased tumor AA concentration decreases, and vascular endothelial growth factor levels and HIF-1, exhibiting anticancer effects [6]. Oral administration of high-dose AA does not result in drug therapeutic levels since the absorption of AA in the intestine is tightly controlled [7], but IV infusion of AA can achieve therapeutic plasma concentration [8]. High-dose IV AA is used as an alternative treatment for. The objective of this study was to evaluate the pharmacokinetic profiles and safety of high-dose AA after IV infusion and determine the potential therapeutic concentration of AA in healthy dogs, so that high-dose AA may be applied to treat cancer in dogs
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