Abstract
Rats were exposed by inhalation for 6 hr to 20 or 154 ppm of 2-[ 14C]nitropropane (2-[ 14C]NP) and the disposition of radioactivity in these animals was followed for 48 hr. These data indicate that at least 40% of the inhaled 2-[ 14C]NP was absorbed. 2-[ 14C]NP was rapidly metabolized and eliminated, and thus has a low potential to accumulate in the rat during prolonged or repeated exposures. Numerous differences were observed in the disposition of 2-[ 14C]NP at the two exposure concentrations that indicate the kinetics of 2-[ 14C]NP were nonlinear in rats at the 154 ppm exposure concentration. These changes in the fate of 2-[ 14C]NP are consistent with and may explain the marked increase in the toxicity observed by others when rats were exposed to high concentrations (≥200 ppm) of 2-nitropropane.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
