Abstract
After oral administration of 200 mg Ciprofibrate (1) to 10 patients, who were cholecystectomated with subsequent T-drainage, 1 could be determined in the collected bile only as its 1-O-beta-acylglucuronide to a very small amount. Approximative calculations have shown that two days after a single dose, less than 0.5% of the administered dose of 1 is excreted on the biliary route. It is an unsolved problem if there is an increase of biliary excretion after multiple dose.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have