Abstract
In recent years preparations of the vitamin B12 group, synthesized at the "Vitaminy" Scientific-Industrial Association hydroxycobalamin (OHCbl) and adenosylcobalamin (AdoCbl) have been finding use in medicine [i]. Together with methylcobalamin, these substances are natural forms of vitamin B12, which are present in substantial amounts in the human and animal organism. OHCbl and AdoCbl have a number of advantages in comparison with cyanocobalamin (CNCbl) lower toxicity, the presence of an anabolic effect, lipotropic and hematoprotective properties, etc. [2]. In view of this, there is a basis for believing that the spectrum of their medical use will widen. However, the pharmacokinetics of these domestic preparations have not been studied. Nor are there any data in the literature on the pharmacokinetic parameters for CNCbl, AdoCbl and OHCbl. Therefore we have begun a study of the pharmacokinetics of preparations of the vitamin Bl2 group.
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