Abstract
The pharmacokinetic data concerning heparin and dermatan sulfate are usually based upon the disappearance of the biological activities generated after parenteral administration, and not upon the direct determination of their chemical concentrations. At least for heparin, these biological activities are mainly related to the polysaccharide chain length and to the antithrombin III affinity, two factors which largely influence heparin clearance. A good understanding of the pharmacokinetic properties of these glycosaminoglycans needs several complementary approaches which may provide conflicting results reflecting the functional and structural heterogeneity of these compounds.
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