Abstract
The pharmacokinetics of furosemide were studied in 12 patients with advanced renal failure. The elimination half‐life of furosemide averaged 9.7 hours. Renal furosemide clearance was reduced, but furosemide elimination by non renal mechanisms was unimpaired in uremic patients without liver disease and accounted for 86% to 98% of total elimination. Nonrenal furosemide clearance also was reduced in 3 uremic patients with liver cirrhosis, and elimination half‐life was prolonged to 20 hours in 1 of these patients. The diuretic response to intravenous furosemide appeared to be adversely affected by poor renal function and dehydration. Diuretic response was always less after oral than after intravenous furosemide, and the slow, intravenous infusion of this drug is recommended for maximal efficacy in uremic patients.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
