Abstract
The pharmacokinetics of enrofloxacin (EFL) and its active metabolite ciprofloxacin (CIP) was investigated in 7–8 month old turkeys (6 birds per sex). EFL was administered intravenously ( i.v.) and orally ( p.o.) at a dose 10 mg kg −1 body weight. Blood was taken prior to and at 0.17, 0.33, 0.5, 1, 2, 3, 4, 6, 8, 10 and 24 h following drug administration. The concentrations of EFL and CIP in blood serum were determined by high-performance liquid chromatography (HPLC). Serum concentrations versus time were analysed by a noncompartmental analysis. The elimination half-live and the mean residence time of EFL after i.v. injection for the serum were after oral administration 6.64 ± 0.90 h, 8.96 ± 1.18 h and 6.92 ± 0.97 h, 11.91 ± 1.87 h, respectively. After single p.o. administration, EFL was absorbed slowly (MAT = 2.76 ± 0.48 h) with time to reach maximum serum concentrations of 6.33 ± 2.54 h. Maximum serum concentrations was 1.23 ± 0.30 μg mL −1. Oral bioavailability for for EFL after oral administration was found to be 69.20 ± 1.49%. The ratios C max/MIC and AUC 0→24/MIC were respectively from 161.23 ± 5.9 h to 12.90 ± 0.5 h for the pharmacodynamic predictor C max/MIC, and from 2153.44 ± 66.6 h to 137.82 ± 4.27 h for AUC 0→24/MIC, for the different clinically significant microorganisms, whose values for MIC varies from 0.008 μg L −1 to 0.125 μg mL −1.
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