Abstract
M.-P. Guo, Q.-C. Wang and G.-F. Liu. Pharmacokinetics of cytotoxin from Chinese cobra ( Naja naja atra) venom. Toxicon 31, 339–343, 1993.—The pharmacokinetics of cytotoxin from Chinese cobra ( Naja naja atra) venom was studied in rabbits after i.v. and i.m. injection of 0.2 and 0.5 mg.kg −1, respectively. The plasma levels of the cytotoxin were analysed by a biotinavidin enzyme-linked immunosorbent assay. The plasma concentration-time course after i.v. administration fitted a two-compartment open model. The half-life (mean ± S.D.) of the α-phase was 5.8 ± 0.6 min and that of the β-phase 3.5 ± 0.2 hr. Apparent volume of distribution was 1.7 ± 0.3 litres.kg −1, and clearance was 5.6 ± 1.4 ml.min −1. A rapid absorption was observed after i.m. injection with peak plasma level of 260 ± 90 ng.ml −1 reached within 13.6 ± 12.4 min. The absorption rate constant was 0.16 ± 0.03 ml −1. The area under the plasma concentration-time curve was 33 ± 15 μg.min.ml −1.
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