Abstract
-1 , which declined to 0.2 ± 0.1 µg.ml -1 at 24 hrs. The absorption half-life (t1/2Ka) and elimination half-life (t1/2 β) were 0.19 ± 0.03 hr and 2.39 ± 0.05 hr, respectively. The area under the plasma concentration-time curve (AUC), area under the first moment curve (AUMC), apparent volume of distribution (Vdarea), total body clearance (ClB), mean residence time (MRT) and total duration of therapeutic effect (td) were 28.7 ± 1.9 µg.ml -1 .hr, 107.7 ± 6.7 µg.ml -1 .hr 2 , 0.42 ± 0.01 L.kg -1 , 0.12 ± 0.003 L.kg -1 .hr -1 , 3.76 ± 0.04 hr and 12.7 ± 0.3 hr, respectively. The systemic bioavailability (F) after IM administration of cefpirome in calves was 35.3 ± 3.1%. To maintain a minimum therapeutic concentration of 0.25 µg.ml -1 , a satisfactory dosage regimen of
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