Abstract
Carprofen was administered intravenously to sheep at two dose rates (0·7 and 4·0 mg kg −1), and the pharmacokinetics of the drug studied. Plasma concentrations of the drug were measured by high performance liquid chromatography. Carprofen had a small volume of distribution (Vd[area], 95·5 and 118·4 ml kg −1), a prolonged elimination half-life ( t 1 2 β , 26·1 and 33·7 hours) and a slow body clearance rate (Clb, 2·5 ml kg −1 h −1) in sheep.
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