Abstract
The pharmacokinetic properties and tissue distribution of enrofloxacin (EF) were investigated after single intramuscular (i.m.) dose of 10mg/kg body weight (b.w.) in Pacific white shrimp at 22 to 25°C. EF and its metabolite ciprofloxacin (CF) were determined by high-performance liquid chromatography. After i.m. administration, EF was absorbed quickly, and the peak of EF concentration (Cmax ) reached at first time point in hemolymph. The volume of distribution Vd(area) of EF was 3.84L/kg, indicating that the distribution of EF was good. The area under the concentration-time curve (AUC) of EF was 90.1 and 274.2μghr/ml in muscle and hepatopancreas, respectively, which was higher than 75.8μghr/ml in hemolymph. The EF elimination was slow in muscle and hepatopancreas with the half-life (T1/2β ) of 52.3 and 75.8hr, respectively. CF, the mainly metabolite of EF, was detected in hemolymph, muscle and hepatopancreas. The Cmax was 0.030, 0.013 and 0.218μg/ml, respectively. Based on a minimum inhibitory concentration (MIC) of 0.006-0.032μg/ml for susceptible strains, EF i.m. injected at a dose 10mg/kg could be efficacious against common pathogenic bacteria of Pacific white shrimp.
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