Abstract
AbstractTransdermal delivery systems have gained wide acceptance over the past decade. These systems allow more control over the surface area and, therefore, the doses delivered to a patient compared to conventional ointments and creams; however, as with ointments, the skin and not the delivery system controls the absorption rate for most drugs. The in vivo percutaneous absorption of nitroglycerin, a highly potent cardiovascular drug with good absorption characteristics, has been investigated over the course of 5 years in more than 300 subjects. Various types of delivery systems, utilizing gel and adhesive matrices and “membrane control” were included in these investigations. Each subject received at least two different formulations on 2 different days. The delivery systems were left in place for 24 hr, after which they were removed and subsequently analyzed for residual nitroglycerin content. The apparent dose for each subject was determined. This parameter is defined as the difference between the initia...
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