Abstract
The pharmacokinetics (PK) of aspirin are described through serum salicylic acid levels, while pharmacodynamics (PD) can be assessed through platelet activity measures, such as Platelet Function Assay (PFA-100) clotting time (seconds (s)). PFA-100 time increases with aspirin mediated platelet inhibition. There is scant literature on the PK/PD of aspirin in pregnancy. The objective of this study is to define the pharmacokinetics and pharmacodynamics of aspirin through gestation.
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