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Abstract
Two premix products containing the endectocide ivermectin were compared for pharmacokinetic profiles and bioequivalence in young pigs. Test and reference articles were administered to individual pigs in-feed at 12-h intervals for a total of 14 doses. Plasma concentration-time profiles were compared after provision of the final doses of medicated feed, by which time steady-state concentrations of ivermectin had been achieved. The pharmacokinetic variables monitored were peak concentration (Cmax ), area under the curve (AUC)0-last , elimination half-life of the terminal phase (T1/2 λz) and average steady-state concentration (Css ), determined by noncompartmental analysis. Logarithmic transformation of the variables was carried out when appropriate. Analysis of data by the Classic Method yielded confidence intervals of 80.59-114.47 (for AUC0-last ), 90.38-119.68 (for Cmax ) and 84.70-111.96 (for Css ). It was concluded that the two articles were bioequivalent for ivermectin.
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