Abstract
The aim of this study was to evaluate the pharmacokinetics and bioavailability of cefquinome (CFQ) and ceftriaxone (CTX) following intravenous (IV) and intramuscular (IM) administrations in premature calves. Using a parallel design, 24 premature calves were randomly divided into the two antibiotic groups. Each of the six animals in the first group received CFQ (2mg/kg) through IV or IM administration. The second group received CTX (20mg/kg) via the same administration route. Plasma concentrations of the drugs were analyzed by high-performance liquid chromatography and noncompartmental methods. Mean pharmacokinetic parameters of CFQ and CTX following IV administration were as follows: elimination half-life (t1/2λz ) 1.85 and 3.31hr, area under the plasma concentration-time curve (AUC0-∞ ) 15.74 and 174hr*μg/ml, volume of distribution at steady-state 0.37 and 0.45L/kg, and total body clearance 0.13 and 0.12Lhr-1 kg-1 , respectively. Mean pharmacokinetic parameters of CFQ and CTX after IM injection were as follows: peak concentration 4.56 and 25.04μg/ml, time to reach peak concentration 1 and 1.5hr, t1/2λz 4.74 and 3.62hr, and AUC0-∞ 22.75 and 147hr*μg/ml, respectively. The bioavailability of CFQ and CTX after IM injection was 141% and 79%, respectively. IM administration of CFQ (2mg/kg) and CTX (20mg/kg) can be recommended at 12-hr interval for treating infections caused by susceptible bacteria, with minimum inhibitory concentration values of ≤0.5 and ≤4μg/ml, respectively, in premature calves. However, further research is indicated to assess the pharmacokinetic parameters following multiple doses of the drug in premature calves.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have