Pharmacokinetic study of oxytetracycline in fish. I. Absorption, distribution and accumulation in rainbow trout in freshwater

Abstract

The absorption, distribution and elimination of oxytetracycline in plasma, muscle, liver, intestine, mucus, skin and vertebrae in rainbow trout in freshwater were studied after a single dose of 150 mg/kg fish. The absorption of the drug was slow and only about 2.6% of the administered dose was absorbed at the time of maximum absorption. The distribution to all tissues of the fish was good, and a considerable affinity of OTC to tissues was observed. The slow elimination was demonstrated by the long halflife which was 11.6 days from plasma.