Abstract
The absorption, distribution and elimination of oxytetracycline in plasma, muscle, liver, intestine, mucus, skin and vertebrae in rainbow trout in freshwater were studied after a single dose of 150 mg/kg fish. The absorption of the drug was slow and only about 2.6% of the administered dose was absorbed at the time of maximum absorption. The distribution to all tissues of the fish was good, and a considerable affinity of OTC to tissues was observed. The slow elimination was demonstrated by the long halflife which was 11.6 days from plasma.
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