Abstract
Healthy volunteers were dosed with digoxin tablets. Blood and urine samples were taken following an established protocol, and were assayed using Lanoxitest γ radioimmunoassay. Blood and urine data were fitted simultaneously to both 3 and 4 exponential functions of the type (Qe −k at + Ae −αt + Be −βt) and (Qe −k at + Ae −βt + Be −βt + Ce −πt). The relevant mathematics for both procedures have been defined. The non-linear leastsquares-fitting programmes used were NAG Subroutine Library and NONLIN. Both indicated that the kinetics of oral digoxin were best represented by a classical two-compartment linear model.
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