Abstract
Amoxicillin was administered as a single subcutaneous injection at 12.5mg/kg to four koalas and changes in amoxicillin plasma concentrations over 24hr were quantified. Amoxicillin had a relatively low average±SD maximum plasma concentration (Cmax ) of 1.72±0.47µg/ml; at an average±SD time to reach Cmax (Tmax ) of 2.25±1.26hr, and an elimination half-life of 4.38±2.40hr. The pharmacokinetic profile indicated relatively poor subcutaneous absorption. A metabolite was also identified, likely associated with glucuronic acid conjugation. Bacterial growth inhibition assays demonstrated that all plasma samples other than t=0hr, inhibited the growth of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 29213 to some extent. Calculated pharmacokinetic indices were used to predict whether this dose could attain a plasma concentration to inhibit some susceptible Gram-negative and Gram-positive pathogens. It was predicted that a twice daily dose of 12.5 mg/kg would be efficacious to inhibit susceptible bacteria with an amoxicillin minimum inhibitory concentration (MIC)≤0.75µg/ml such as susceptible Bordetella bronchiseptica, E.coli, Staphylococcus spp. and Streptococcus spp. pathogens.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of veterinary pharmacology and therapeutics
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
