Abstract
AbstractPharmacokinetic modeling is used to describe and predict concentration–time profile of a drug in the body. Common pharmacokinetic modeling approaches include noncompartmental analysis and compartmental modeling. Noncompartmental analysis is based on the statistical moment theory, while compartmental analysis is based on a mathematical model as a representation of the body to define model parameters by fitting the model to drug concentration–time data. This chapter serves to provide concepts and a set of guidelines for pharmacokinetic analysis using noncompartmental analysis and compartmental modeling approaches.KeywordsPharmacokineticsNon-compartmental analysisCompartmental AnalysisNon-linear pharmacokineticsMetabolite pharmacokinetics
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