Abstract
The dynamic characteristics of a transcorneal drug delivery after dose instillation is simulated by a pharmacokinetic model, which takes into consideration the corneal diffusion, metabolism, binding, aqueous-humor elimination, tear flow dynamics, and tissue distributions. Analyses are made of the effects of the tear-fluid elimination rate, of the diffusion coefficient and partition coefficient in the epithelium and stroma, of corneal metabolism, and of binding on the concentration profile in the aqueous humor and on tissue concentrations. The present pharmacokinetic model can be used for gaining a quantitative understanding of the effect of various parameters on the ocular bioavailability after dose instillation.
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