Abstract
Pharmacokinetic Interactions between Intravenous Ciprofloxacin and Oral Ferrous Sulfate
Highlights
Abstract | The changes in the bioavailability of oral antimicrobial activity in in vitro focus of many of the previous studies of the interaction of metal cations and quinolones
This study is the first to examine the possibility of interaction in the blood circulation using ciprofloxacin and ferrous sulfate as representative in the dogs model, and identify changes, if any, in the pharmaceutical antibiotics
Results showed that the disposition of ciprofloxacin in control animals was biexponential with a terminal elimination half-life (5.33 ± 0.14),(7.70 ± 0.08) respectively.The volume of distribution (Vd, 1.10± 0.15 L/kg), (Vd, 1.68 ± 0.33L/kg) was observed.When the antibiotic was dosed with oral iron, appeared to show a wider distribution and a longer elimination of ciprofloxacin relative to controls, antibiotic exposure (AUC 0-∞ ) was significantly higher in the presence of iron (65.43 ± 1.60, 67.95 ± 1.78mg/ml/hr.)
Summary
Abstract | The changes in the bioavailability of oral antimicrobial activity in in vitro focus of many of the previous studies of the interaction of metal cations and quinolones. The current study design required the dogs (2.5 –3.5 Kg) to be dosed with 100 mg/kg of oral ferrous sulfate and 10 mg/kg of intravenous ciprofloxacin. The main difference between ciprofloxacin and other antibiotics is that it can be administered parentally, topically and orally. It is well absorbed and widely distributed into various body tissues and fluids. Concurrent oral administration of 500 mg of ciprofloxacin with 100 mg of ferrous sulfate significant reductions in the area under concentration vs time curve, peak plasma concentration and urinary recovery of antibiotics as much as 57%, 54% and 58%, the respectively
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