Abstract
Antihypertensive and antianginal actions of β-adrenoceptor blocking agents and calcium antagonists are synergistic. 1 However, combination use is compromised by adverse effects. 2–5 Although pharmacodynamic synergism contributes to adverse reactions, recent studies suggest that the combination of lipophilic β-blocking drugs with calcium-blocking agents results in pharmacokinetic interactions. 6 In the present study we investigated the possibility of pharmacokinetic interaction between metoprolol and verapamil for angina pectoris.
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