Pharmacokinetic implications of albendazole biotransformation in goats following interaction with curcuma longa

Abstract

To test the hypothesis that Curcuma longa could act as hepatic microsomal cytochrome P450 inhibitor resulting in increased bioavailability of albendazole, a study was undertaken to understand the pharmacokinetics and efficacy of albendazole in goats with and without coadministration of albendazole with hydroalcoholic extract of Curcuma longa at 7.5 and 500.0 mg per kg body weight, respectively. The comparative pharmacokinetic values (Mean±S.E.) of albendazole sulphoxide in goats using albendazole and albendazole combination revealed significantly (P<0.05) reduced values of concentration maximum, area under concentration-time curve and total area under the first movement of plasma drug concentration-time curve (P<0.001) in goats receiving albendazole and Curcuma long a. Significantly lower values of under concentration-time curve in goats receiving albendazole in combination with Curcuma longa had resulted in relative bioavailability of 0.57. Estimated drug-parasite contact of albendazole sulphoxide in goats revealed significantly decreased values in goats receiving ABZ combination. Nematode parasites of goats dominated by Haemonchus contortus also exhibited resistant against benzimidazole following administration of albendazole alone and in combination with Curcuma longa. Simultaneous administration of hydroalcoholic extract of Curcuma longa, contrary to the hypothesis, resulted in reduced bioavailability of albendazole.